Ferulic acid and phloretin are the active ingredients in PerioSciences dental antioxidant products. They are antioxidants in a category known as polyphenols. Other than actual chemists and scientists, and perhaps the occasional organic chemistry student, most people don’t know very much about polyphenols, antioxidants, or ferulic acid and phloretin. This post started with the objective of researching polyphenols to explain how they work and why they are effective antioxidants.
Here are some somewhat interesting factoids.
• Phloretin is a flavonoid, one class of polyphenols. Flavonoids have 15 carbon atoms. Many flavonoids are found in plants, and phloretin is found in the leaves of apples. Some flavonoids are powerful antioxidants.
• Ferulic is a polyphenol, a “natural phenol,” but not a flavonoid. It is a phytochemical found in the cell walls of plants such as wheat, rice, peanuts, oranges and apples, and coffee. As an antioxidant, it can seek and destroy several different types of free radicals, including superoxide, hydroxyl radical, and nitric oxide.
• Research abounds on polyphenols and their antibacterial and antioxidant properties. Since there are zillions of polyphenols, there are more articles and research papers out there than this blog can shake a stick at.
This post didn’t get very far with the research and understanding. You are invited to go to the internet, an organic chemistry textbook, or your friendly neighborhood biochemist for a fuller explanation of the science and chemistry of polyphenols and antioxidants.
Our scientific background
And that, dear reader, may be the main point of this post. PerioSciences LLC has a slogan, “Serious Science. Serious Products.” Behind the social media, the public relations, the marketing, the packaging, and the manufacturing, there is a deep infrastructure of antioxidant science, research, and development. The company started in 2008 with a handful of antioxidants that had been extensively tested on skin cells by the Department of Dermatology at Duke University.
More than a decade of research on these antioxidants proved that they could counteract the damage caused by ultraviolet (UV) rays. The UV rays cause chemicals in the skin cells to break down and release free radicals, but the antioxidants neutralize the free radicals, halting a chain-reaction that can result in cell damage. Not surprisingly, a substance that can protect skin cells from UV damage—also known as photo-aging—has been a boon to the skin care world. Dermatologists and aestheticians caught on, and soon the product line known as SkinCeuticals began—the first in the category of “cosmeceuticals.”
In 2008, PerioSciences initiated further research and development to see if the same antioxidants could have an effect on other “skin” cells. This time, the cells were oral cells, in and around the mouth. For this, PerioSciences enlisted the help of scientists at Texas A&M University Baylor College of Dentistry to test the effects of antioxidants on oral cells, especially with regard to toxic substances such as nicotine, hydrogen peroxide, and alcohol. In addition, PerioSciences teamed with scientists at the University of North Carolina at Chapel Hill School of Dentistry. Here, the sophisticated research concentrates on the role of antioxidants in reducing inflammatory markers.
Besides this university-based research, PerioSciences has been working with clinicians—dental hygienists, dentists, periodontists, and other specialists in dental medicine—to assess and quantify how AO ProVantage dental antioxidants can best be used among real patients. These dental professionals are sharing their findings and case studies in technical journals, dental conferences and seminars across the country.
PerioSciences also invests in research and development for new products. Our biochemistry lab is constantly experimenting with different combinations of antioxidants and different concentrations, as well as other ingredients for advanced oral care products.
This blog wasn’t able to come up with much that’s intelligible about polyphenol antioxidants. Fortunately, this blog doesn’t have to. PerioSciences LLC has more than enough intelligence about antioxidants, how they behave, where they come from, how they benefit dental patients, and much more. That’s all serious science.
And that’s where the serious products of PerioSciences come from.