Seriously Seeking Science

The Bite Of Teeth WhiteningFerulic acid and phloretin are the active ingredients in PerioSciences dental antioxidant products. They are antioxidants in a category known as polyphenols. Other than actual chemists and scientists, and perhaps the occasional organic chemistry student, most people don’t know very much about polyphenols, antioxidants, or ferulic acid and phloretin. This post started with the objective of researching polyphenols to explain how they work and why they are effective antioxidants.

Here are some somewhat interesting factoids.

• Phloretin is a flavonoid, one class of polyphenols. Flavonoids have 15 carbon atoms. Many flavonoids are found in plants, and phloretin is found in the leaves of apples. Some flavonoids are powerful antioxidants.
• Ferulic is a polyphenol, a “natural phenol,” but not a flavonoid. It is a phytochemical found in the cell walls of plants such as wheat, rice, peanuts, oranges and apples, and coffee. As an antioxidant, it can seek and destroy several different types of free radicals, including superoxide, hydroxyl radical, and nitric oxide.
• Research abounds on polyphenols and their antibacterial and antioxidant properties. Since there are zillions of polyphenols, there are more articles and research papers out there than this blog can shake a stick at.

This post didn’t get very far with the research and understanding. You are invited to go to the internet, an organic chemistry textbook, or your friendly neighborhood biochemist for a fuller explanation of the science and chemistry of polyphenols and antioxidants.

Our scientific background

And that, dear reader, may be the main point of this post. PerioSciences LLC has a slogan, “Serious Science. Serious Products.” Behind the social media, the public relations, the marketing, the packaging, and the manufacturing, there is a deep infrastructure of antioxidant science, research, and development. The company started in 2008 with a handful of antioxidants that had been extensively tested on skin cells by the Department of Dermatology at Duke University.

More than a decade of research on these antioxidants proved that they could counteract the damage caused by ultraviolet (UV) rays. The UV rays cause chemicals in the skin cells to break down and release free radicals, but the antioxidants neutralize the free radicals, halting a chain-reaction that can result in cell damage. Not surprisingly, a substance that can protect skin cells from UV damage—also known as photo-aging—has been a boon to the skin care world. Dermatologists and aestheticians caught on, and soon the product line known as SkinCeuticals began—the first in the category of “cosmeceuticals.”

Scientific partners

In 2008, PerioSciences initiated further research and development to see if the same antioxidants could have an effect on other “skin” cells. This time, the cells were oral cells, in and around the mouth. For this, PerioSciences enlisted the help of scientists at Texas A&M University Baylor College of Dentistry to test the effects of antioxidants on oral cells, especially with regard to toxic substances such as nicotine, hydrogen peroxide, and alcohol. In addition, PerioSciences teamed with scientists at the University of North Carolina at Chapel Hill School of Dentistry. Here, the sophisticated research concentrates on the role of antioxidants in reducing inflammatory markers.

Besides this university-based research, PerioSciences has been working with clinicians—dental hygienists, dentists, periodontists, and other specialists in dental medicine—to assess and quantify how AO ProVantage dental antioxidants can best be used among real patients. These dental professionals are sharing their findings and case studies in technical journals, dental conferences and seminars across the country.

PerioSciences also invests in research and development for new products. Our biochemistry lab is constantly experimenting with different combinations of antioxidants and different concentrations, as well as other ingredients for advanced oral care products.

This blog wasn’t able to come up with much that’s intelligible about polyphenol antioxidants. Fortunately, this blog doesn’t have to. PerioSciences LLC has more than enough intelligence about antioxidants, how they behave, where they come from, how they benefit dental patients, and much more. That’s all serious science.

And that’s where the serious products of PerioSciences come from.

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Speaking of Tongues: Lingua geographica, or Geographic Tongue

Benign migratory glossitis, oral erythema migrans, glossitis areata exfoliativa, glossitis areata migrans, lingua geographica, stomatitis areata migrans, and transitory benign plaques of the tongue. These are some of the names for a condition more often known as “geographic tongue.”

It’s not very common; only about 2 percent of the population have it. Unfortunately, it’s a chronic disease, so those who get geographic tongue probably get it pretty often. And it’s not that worrisome. Geographic tongue doesn’t spread to other parts of the body; it doesn’t transform to cancer; it’s not contagious; and most likely, no one ever died from it.

The cause of geographic tongue is not known for sure. It seems to be more common with people who have environmental sensitivities such as allergies, eczema or asthma. Nutrition might play a part, such as zinc or vitamin B deficiencies. Spicy foods, alcohol or burning your tongue on hot foods may bring on geographic tongue. Surprisingly, according to the A.D.A.M. Medical Encyclopedia, geographic tongue is less common among people who smoke.

What it’s like

They call it geographic tongue because there are flat, oddly-colored patches that almost look like a map. The flat patches, which can change from day to day, are the result of a loss of the tiny papillae, finger-like projections, on the surface of the tongue. Sometimes the patches are pale, but they can also be smooth and red. Tenderness is not uncommon. While geographic tongue is harmless (although annoying), it is not generally serious. Symptoms that do warrant seeking medical help are severe swelling or trouble breathing, speaking, chewing or swallowing.

What to do about it

There are not any common treatments for geographic tongue. People are advised to avoid foods that trigger it, and some people find relief from mint leaves, candy or gum. Some dentists might prescribe topical steroid ointments, antihistamines or zinc lozenges.

Or, they might try something completely different. Dr. Edward P. Allen, a nationally known periodontist, provided a case study of a 35-year-old male with chronic, recurring geographic tongue. Dr. Allen has had excellent results recommending AO ProVantage dental gel for patients with inflammation of the gums or who have had dental procedures. He recommended AO ProVantage dental gel for the patients two times daily. He also took photographs of the patient’s tongue at the beginning of treatment, and again after two weeks, six weeks, and six months. The patient experienced fewer episodes of geographic tongue, and when it flared up, it occurred in a reduced area of the tongue and resolved more rapidly.

AO ProVantage from PerioSciences is a cooling, minty dental gel that soothes oral tissues and freshens breath. It adds to the appearance of healthy-looking gums – and tongues.

PerioSciences is dedicated to innovating antioxidant use and providing the best oral care products. If you would like to learn more about antioxidants in oral care and our products, join us on Facebook, Twitter and LinkedIn!

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On A Quest For A DDS?

On A Quest For A DDSFinding a new dentist can be a daunting challenge. Whether you are looking for a specialist for urgent needs or just someone to check out your oral health a couple of times each year, it’s an important task of evaluation. With a bit of research and thought, you can find a trusted partner for your health care.

Need a specialist?

To start, decide what kind of dentist you want. You may need to find a specialist for certain conditions. Periodontists specialize in the gums and other tissues surrounding the teeth. Endodontists deal with the inside of teeth, the pulp and roots. Orthodontists straighten teeth and help with skeletal and muscular problems in the face and jaws. Oral and maxillofacial surgeons treat diseases, injuries and defects of the hard and soft tissues. Prosthodontists work with patients who are missing teeth for any number of reasons. These specialties are recognized by the American Dental Association, and the practitioners must meet certain requirements and be certified by licensing boards.

There are also dentists who specialize by the types of patients they treat. Pediatric dentists specialize in children’s oral conditions, and some dentists have a large clientele of elderly people. Dentists may have special experience in treating patients with conditions such as diabetes, HIV/AIDs, autism, physical handicaps, cancer, and so on.

Ask those in the know

If you are searching for a dentist, one place to start is the American Dental Association’s website. The ADA website also provides information about the various specialties and can help locate board-certified practitioners. You can also use other searching sites or local business directories. Personal recommendations are especially helpful. Ask your physician or a pharmacist, and query your family and friends, neighbors, co-workers, church members, and others.

Getting down to specifics

After you develop a list of candidates, you will want to do some research on some of the basic issues. Where is the office? What are the hours of operation? Does the dentist take your insurance? Is the dentist taking new patients? Most of these questions can be answered by a quick phone call to the office.

You may also want to research some of the aspects of doing business with this professional. For example, you might ask how long is the normal wait to make an appointment? Are you charged if you miss or break an appointment? Does the dentist provide emergency or after hours care? Will they file insurance claims, or will you need to do that? Does the dentist accept your co-pay, or do you have to pay up front and be reimbursed by your insurance company later? How about financing and payment plans? You may be able to get an answer on the first phone call to the office, or you may want to speak to the office manager for a more detailed conversation.

Once you’ve decided on a dentist to visit, you may add some additional criteria to your evaluation. For starters, how do you feel about the office staff? Are they professional and efficient? Are they friendly, or at least not annoying? Do you get in and out of the office in reasonable time? As for the dentist and the hygienist, are you able to establish some rapport or chemistry? See if you can determine the level of interest in your whole-body health and in you as a person. After all, you are more than just a mouthful of teeth, and your oral health and comfort are fundamental to your overall health and well-being.

Up to date is essential

You should also try to determine if the dental office has up-to-date equipment. Ask the dentist and hygienist about their continuing education courses and how they stay on top of the latest research. For example, has your dentist been reading about the emerging application of topical antioxidants in oral care? How attuned is the dentist to the problems of oxidative stress on oral tissues caused by chronic illness, stress, environmental pollutants, and toxic substances such as alcohol, nicotine, and dental materials? Can he or she explain the link between oral disease, inflammation and systemic disease?

Ask the dentist about whether the office provides AO ProVantage dental gel or AO ProRinse. An increasing number of dentists and hygienists are learning about the advantages of incorporating topical antioxidants as part of a routine office visit and recommending PerioSciences products as part of regular oral hygiene, including for patients with special conditions or recovering from oral procedures.

The ideal dentists will be on top of their profession, up to date with technology and education, and ready to focus on your needs. Those dentists are out there and with a little effort and some good questions, you can find them.

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The Bite of Teeth Whitening

The Bite Of Teeth WhiteningThe movie screen is filled with a weird image of a gaping mouth, with dental retractors and teeth gleaming under an eerie white light. The focus pulls away and we realize the mouth belongs to George Clooney in the 2003 movie Intolerable Cruelty. And George, as shark-like divorce attorney Miles Massey, is having his teeth power-whitened.

Movie stars, celebrities (and high-profile divorce attorneys) are not the only people anxious to have gleaming, white teeth. An estimated ten million Americans buy teeth whitening products and services this year, to the tune of $1.7 billion. If you are one of them, be glad that you’re whitening your teeth in the 21st century. It is believed that the ancient Romans used human urine to strengthen and whiten teeth. Since the mid-1800s, dentists have been using hydrogen peroxide to bleach teeth. By the 1980s, teeth whitening became one of the most common dental treatments.

Sources of stains

Lots of things can stain your teeth, such as coffee and tea, grape juice, red wine or other colored beverages. Nicotine from tobacco products are notorious for turning teeth yellow. Some diseases and normal aging will discolor teeth. Also, medications, such as tetracycline can stain teeth; so can certain dental substances, such as excessive fluoride or chlorhexidine used as an antibacterial rinse.

The first layer on a tooth is the enamel, which is clear and transparent. The next layer is the dentin, a spongy substance that is normally yellowish, but can be gray, brown or even black. In teeth whitening, hydrogen peroxide opens the pores of the enamel on the tooth in order to penetrate the layer of dentin and bleach out the color. Hydrogen peroxide is the primary bleaching agent. Some treatments use carbamide peroxide, which is essentially hydrogen peroxide that has an added urea molecule.

Professional and OTC whitening

Not surprisingly, the most effective teeth whitening is performed by professional dentists. Dentists commonly use hydrogen peroxide in concentrations ranging from 15 percent to 35 percent. Sometimes treatments will include light or lasers to accelerate the whitening process.

You can also ask your dentist for an at-home treatment kit. This may include custom-made trays that fit your teeth to hold a special bleaching solution in contact with the enamel surface. The at-home kit option will include the cost of the dental office visit, but some dentists will provide the kits for free as an incentive for new patients.

A wide array of teeth-whitening products are available over the counter. Whitening strips come in varying strengths, and whitening toothpastes or rinses can help keep treated teeth whiter for a little while longer. Whitening toothpastes contain polishing or chemical agents that remove stains without bleaching.

Safety and sensitivity

Teeth whitening is generally considered safe, but there are at least two major drawbacks from teeth whitening (other than cost, of course). First, opening the pores, or dentinal tubules, in the teeth with hydrogen peroxide can result in pain and sensitivity. Sensitive formula toothpastes, which remineralize the enamel and close up the tubules, may be helpful.

The other drawback is that many people complain about irritated gums following whitening treatment. No wonder. The hydrogen peroxide can be extremely irritating or even deadly to oral cells. Scientists at Texas A&M Health Science Center Baylor College of Dentistry (BCD) in Dallas, Texas did some experiments with oral cells—the cells that make up the ligaments holding teeth in place and the cells that become gingival or gum tissue. They exposed the cells to toxic substances including nicotine, alcohol, and hydrogen peroxide. At high concentrations, the oral cells died. At lower concentrations, they just ceased to multiply as needed for growth and healing.

Then the researchers exposed the oral cells to the toxins again, but this time they treated them with different concentrations and combinations of antioxidants including phloretin and ferulic acid. They found that the antioxidants significantly counteracted the effects of hydrogen peroxide by increasing the cell viability and survival. They also noted that antioxidants decreased the production of reactive oxygen species (ROS), or free radicals. In other words, the combinations of antioxidants protected these oral cells from the free radical damage caused by hydrogen peroxide.

The same antioxidants, phloretin and ferulic acid, are the basis of PerioSciences AO ProVantage dental gel and AO ProRinse mouth wash and AO ProVantage BLAST. These products bring the power of antioxidants to soothe gums and promote healthy-looking oral tissues. Fresh breath and a clean feeling in the mouth are great, too.

Back in 2003, Miles Massey (and George Clooney, for that matter) walked out of the dentist’s office with gleaming white teeth and tender gums. Today, anyone can walk out with whiter teeth, armed with dental antioxidants for an even healthier smile.

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The Case Against Nicotine

Stop SmokingTobacco users should by now be well aware of the health dangers of nicotine. Way back in 1964 the U.S. Surgeon General wrote that nicotine and tar from cigarettes caused lung cancer. In 1965, Congress passed the Cigarette Labeling and Advertising Act, ruling that every cigarette package must have a warning label stating, “Cigarettes may be hazardous to your health.” In 1984, the Comprehensive Smoking Education Act added three additional labels to be printed on cigarette packs.

Smokeless tobacco, which comes in the form of chewing tobacco, snuff or snus, came under fire, too. Effective June 2010, warning labels began to appear on smokeless tobacco products and their advertisements. Research directly linked smokeless tobacco to oral, pharyngeal and laryngeal cancer as well as cancer of the esophagus, gum disease and tooth loss.

Research on antioxidants vs. nicotine

At PerioSciences, we are vitally interested in oral health. Our product line of AO ProVantage dental gel, AO ProRinse, and AO ProVantage BLAST includes the antioxidants phloretin and ferulic acid, which work synergistically with the natural antioxidants found in saliva. Our products are cooling, soothing, and refreshing for the breath—and for oral tissues.

We have also followed and funded scientific research on how antioxidants work with oral cells. In particular, we have been following studies at the Texas A&M Health Science Center Baylor College of Dentistry (BCD) in Dallas, Texas. This group has studied the effect of nicotine on oral cells. Their studies have confirmed that nicotine keeps wounds—such as a scratch on oral cells—from healing because it increases reactive oxygen species (ROS, or free radicals). Nicotine also inhibits cells from migrating across a wound to heal it.

The BCD studies also examined the effect of antioxidants on scratch-wounded cells exposed to nicotine. According to their report, published in the Journal of Periodontology, “Treatment with antioxidant combinations clearly counteracted the effects of nicotine by restoring and increasing cell-migration rates…These results clearly demonstrate that [combinations of ferulic acid (F) and phloretin (P)] counteract the negative effects of nicotine ….”

The case of the dippers

Laboratory studies on petri dishes of cultured cells are impressive. But what about actual people? Well, it turns out that dentists and periodontists have been observing the effects of AO ProVantage products on some of their patients. We’re getting lots of positive reports. One periodontist in particular has written a case study about two of his patients who were long-time users of smokeless tobacco. We call them “dippers.” Both patients, 35-year-old men, had developed painful sores between their gum and cheeks—the spot where they stashed their tobacco. Our dentist wasn’t able to convince them to actually stop using the tobacco product. But the patients did find that using AO ProVantage BLAST, which is specifically formulated for people who use nicotine, not only freshened their breath, but more important, also soothed the soft tissue in and around the oral cavity. They reported improved appearance of their oral tissues and a pleasant refreshed feeling—even though they continued to use their smokeless tobacco.

So, if you’re a smoker or if you use smokeless tobacco, we at PerioSciences urge you to break the habit. If you can’t quit, make a new habit of using AO ProVantage BLAST. It’s the least you can do for your mouth.

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Dealing With Dry Mouth

Dealing With Dry MouthYou may have heard of xeriscaping—gardening with minimal use of water. You may have heard of xerography—the process of copying with dry ink toner. But what have you heard about xerostomia?

It’s pronounced zero-STOH-mia, and it’s from two Greek words that mean “dry mouth.” Most people get a dry mouth when they haven’t stayed hydrated or when they are facing an extreme situation of fear or embarrassment. For some people, xerostomia is an ongoing condition that is annoying at the least and debilitating at worst.

Without enough saliva, dry mouth sufferers can have trouble chewing, swallowing, and even speaking. The sticky, dry feeling often interrupts sleep. Some of the other effects of dry mouth include bad breath, decreased taste, and mouth sores. Dry mouth can also cause dental problems including cavities, gum disease and periodontitis.

Reduced function of the salivary glands

Xerostomia results from a malfunction of the salivary glands. There are several glands that produce saliva and they can be damaged in various ways. Prolonged use of prescription medication for allergies, high blood pressure, or depression can bring on xerostomia. Some chronic diseases such as diabetes, hepatitis C, depression, or sarcoidosis are associated with dry mouth. Sjögren’s syndrome is an autoimmune disorder characterized by both dry mouth and dry eyes. Dry mouth is extremely common among patients treated for cancer, especially for those treated for head or neck cancer.

Radiation treatment for cancer can damage the salivary glands, sometimes permanently. The ionizing radiation that destroys tumors also causes changes to the salivary glands and the mucous membranes in the mouth. In addition, radiation can increase reactive oxygen species, ROS, and other free radicals that lead to oxidative stress and DNA damage. It is difficult to quantify the number of people who suffer from dry mouth, although some 30,000 to 40,000 people each year are diagnosed with head and neck cancer. Many people feel that the side effects of xerostomia are even worse than the cancer treatments.

Lessening the damage from radiation

There are three primary ways to prevent or lessen the damage to salivary glands from radiation. Adjusting the dosage or intensity of the radiation beam as well as narrowing the target may lessen the damage to salivary glands and other tissue close to the tumor. A second strategy is to actually transplant some of the salivary glands to another location in the head and neck in advance of radiation. Also, there are medicines that act as protective agents to scavenge free radicals and protect the salivary glands during the course of treatment.

Patients with xerostomia, whether it’s due to radiation or other causes, have a few tools for treating their symptoms. Doctors can prescribe medicines that stimulate the salivary glands, provided they are still functioning. Some patients have found relief with acupuncture, but there is not much scientific research yet that supports this treatment. Most often, people deal with dry mouth by using moistening agents and saliva substitutes. These only provide temporary relief, however, and maybe bad-tasting and expensive.

Replacing saliva and its components

Saliva contains natural antibiotics and antioxidants that part of the body’s defense system, so people with xerostomia are more prone to cavities and various oral infections. When dentists and doctors help patients deal with dry mouth, they often use antibiotics to control any infection. Since inflammation and oxidative stress are a large part of the problem, many practitioners advise using antioxidants because they have been shown to counteract oxidative stress and to mitigate inflammation.

PerioSciences products with topical antioxidants may prove to be helpful for dry mouth conditions. The AO ProVantage dental gel or AO Pro Rinse mouth rinse, flavored with essential oils and xylitol, are pleasant-tasting, cool and refreshing. The antioxidants, including phloretin, ferulic acid and green tea catechins, can nourish and soothe the oral tissues that lack saliva’s natural antioxidants.

If you suffer dry mouth, check with your dentist about the causes and treatments. Be sure to ask about trying AO ProVantage products.

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Happy Mother’s Day! Do You Know Where Your Baby’s Teeth Are?

Baby TeethHappy Mother’s Day—to everyone who is a mother and to everyone who has a mother.

Moms are great, aren’t they? They go to such lengths to care for their families, make sure everyone is fed properly, and keep wailing and tears to a minimum. Unfortunately, some moms may try a little too hard to keep their little ones from crying, and set up their kids for dental catastrophes in the process.

The problem is that even tiny babies need regular dental care—and they probably don’t like it.

Even before teething

The American Dental Association recommends cleaning a baby’s gums as early as possible within the first few days after birth. Following feeding, simply take a clean piece of gauze and gently wipe the gums. The sugars and proteins that are in milk—including mother’s milk or formula—combine with normal bacteria in the mouth to form plaque, the same as in adults.

Baby teeth, which start to come in at about eight to 12 months of age, are susceptible to cavities. Since these teeth are important for chewing and for proper growth and development of the jaws, it’s important to take care of them from the very start.

Happy visits to the dentist

When is the right time to start taking children to the dentist? The ADA recommends a first visit within six months after the first tooth comes in, at least once during the baby’s first year. This visit can be a “well child visit,” and it’s a great time to talk to the dentist about cleaning and caring for the baby’s teeth. After that, children should visit the dentist regularly, just as adults should.

As baby teeth come in, teething can be uncomfortable. Moms can rub the gums gently with a clean finger. A cool spoon or special teething ring may be helpful, too. Your dentist will have suggestions as well.

Teaching a toddler to brush her teeth twice a day may be as appealing to a weary mom as trying to get her to put away her toys. Again, a dentist may have suggestions for tasty toothpaste, child-sized toothbrushes, and hints for making it a pleasant experience for everyone.

Don’t cave in on the sugary drinks

As babies get bigger, moms and dads who feel challenged to get them to settle down for naps or bedtime may resort to giving them a bottle of milk or juice when they lay them in the crib. Here again, the sugars may remain in the baby’s mouth, increasing the possibility of corroding the new baby teeth.

According to a March 6 article in the New York Times, there has been an alarming rise in the number of children with multiple cavities. In fact, some kids come to the dentist with so many, the best method of filling the teeth is under general anesthesia. The article mentions several reasons for such a rise in dental decay in children: Constant eating and drinking, especially sugary drinks; bottled water instead of tap water that contains cavity-fighting fluoride; and improper dental care. This includes skipping the dental visits as well as caving in when a child resists tooth-brushing.

And welcome the Tooth Fairy!

Baby teeth start to loosen and fall out at about age six. These milestones in a child’s life can be exciting for moms as well as for kids. According to a Tooth Fairy website,, the average amount the Tooth Fairy leaves for a child’s tooth is $1.10. Just sayin.

Happy Mother’s Day from all of us at PerioSciences. Want to really treat yourself? Try our cool, refreshing AO ProVantage dental gel or AO Pro Rinse. They taste great, and the antioxidants soothe and nurture your gums and oral tissues, working with the natural antioxidants contained in saliva.

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Oral Health And Conception

Conception & Oral CareThinking about getting pregnant?

Put on the music and turn down the lights. Chill some cocktails. Slip into something alluring. And schedule an appointment with your dentist.

A number of research studies in recent years have shown that oral health can make a difference in pregnancy. Specifically, the bacteria that causes gingivitis and periodontitis, P. gingivalis, can be a bad thing for conception and for healthy, full-term pregnancy.

Low birth weight, premature labor and preeclampsia

A 2007 study published in the Journal of Periodontology found that of 3,576 Turkish women, those with periodontal disease were at greater risk for having a low birth weight and preterm birth babies than those with healthy mouths. The researchers went a little further and found in a second study that nonsurgical treatments for periodontal disease—professional cleaning and bacterial control—can improve the likelihood of carrying the pregnancy to full term.

Another study the same year found that same sinister bacteria, P. gingivalis, in the oral cavity as well as in the amniotic fluid of pregnant women who had been diagnosed with a threat of premature labor. Although the researchers acknowledged that there can be many reasons for preterm labor, bacterial infection of the amniotic fluid could potentially be dangerous to both the mother and the baby. “Past research has shown a relationship between adverse pregnancy outcomes and periodontal disease, a chronic bacterial infection,” stated Gorge Gamonal, the study author. The study was published in the July 2007 issue of Journal of Periodontology.

One more study, also published in Journal of Periodontology in April 2007, found a suspected link between periodontal bacteria and preeclampsia, an abrupt rise in blood pressure that affects about 5 percent of pregnancies. Untreated, preeclampsia can lead to preterm birth and even seizures in the mother. The study found that 50 percent of the placentas from women with preeclampsia were positive for one or more periodontal pathogens. This was more than three times the 14.3 percent found in the control group of women with no preeclampsia.

Difficulty in conception

But it also turns out that periodontal disease can reduce the chances of getting pregnant in the first place. A study from Australia presented at the 2011 Annual Meeting of the European Society of Human Reproduction and Embryology reviewed the cases of 3,416 women. Researchers found that women with gum disease took more than seven months on the average to become pregnant—compared to the average of five months for women without gum disease. For non-Caucasian women, the average length of time to conceive rose to one year.

And, the June 2009 issue of Journal of Sexual Medicine included a study concluding that erectile dysfunction might be associated with chronic periodontal disease. An Israeli study in 2008 found that men with a low sperm count often had gum disease.

So before you start getting romantic, or even if you are already pregnant, make sure your teeth and gums are in top condition. Visit your dentist to deal with any gum disease, and be sure to brush and floss daily.

We at PerioSciences would also suggest a couple of daily doses of AO ProVantage dental gel or AO Pro Rinse. Cool and pleasant tasting, the antioxidants and other ingredients can help soothe and nurture your oral tissues and freshen your breath—helping you get ready for that romantic encounter and maybe a baby!

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PerioSciences In The Spotlight

PerioSciences In The SpotlightThe popular press is shining the light on the AO ProVantage products for beautiful, healthy (and sexy) age-defying smiles. Here are some recent mentions.

• InStyle Magazine, April 2012. “Beauty at Any Age: Make It Last! Sexy Smile; Your key products for your fifties and beyond PerioSciences’ AO ProVantage.”
Click Here To View The Full Article In Instyle Magazine

• Self Magazine, February 2012. “Your Prettiest Smile. Ever.” AO ProVantage is part of the recommendation for Protecting your smile.
Click Here To View The Full Article On Self Magazine

•, November 6, 2011. “Mouth health: Center of the wellness universe,”
Click Here To View The Full Article On Momover

Professional Attention

Professional publications are also turning the examination light on to PerioSciences. Our product line, including AO ProVantage dental gel, AO Pro Rinse and AO ProVantage BLAST stepped into the bright light of media attention during the Chicago Midwinter 2012, the annual meeting of the Chicago Dental Society. Several publications that cover the dental profession picked up the story, including:
• Dr., February 14, 2012. “PerioSciences to unveil antioxidant-based oral care products.”
Click Here To View The Full Article On Dr. Bicuspid

• Corona, February 28, 2012. “PerioSciences Showcases its AO ProVantage Family of Antioxidant Oral Care Products.”
Click Here To View The Full Article On Corona

• Dentistry iQ, February 14, 2012, “AO ProVantage product family to be presented at Chicago Midwinter 2012.”
Click Here To View The Full Article On Dentistry iQ

• Dental Tribune, March 2012.
Click Here To Read The Full Article On Dental Tribue

• The Dental Implant Blog, March 2012
Click Here To Read The Full Article On The Dental Implant Blog

• Dental Compare, March 2012
Click Here To Read The Full Article On Dental Compare

People who attended the conference were impressed with the excitement surrounding PerioSciences and the unveiling of the new product. In addition, two prominent periodontologists were presenters at the conference. Their comments about the promise of dental antioxidants for oral health—including case studies from their own practices—brought dentists, hygienists, and other specialists to the PerioSciences booth clamoring for more information. A substantial portion of Dr. Edward P. Allen’s remarks were published in a recent professional journal.

• Dentistry iQ, January 19, 2012 “Emerging indications: antioxidants for periodontal disease,” by Edward P. Allen, DDS, PhD.
Click Here To Read The Full Article On Dentistry iQ

Also, Dr. Allen and Dr. Sam Low, and Dr. Dennis Abbott were featured in Spark 360 online videos, interviewed by Rene San Miguel. The videos discuss oral health and the oral/systemic link as well as the use of antioxidants for dental patients.

• Spark 360, January 2012. Rene San Miguel interviews Dr. Pat Allen and Dr. Dennis Abbott to learn more about salivary antioxidants and their role in fighting cancer and other oral disease. Both doctors describe the amazing success they’ve seen with AO ProVantage on their patients with oral cancer.
Click Here To Watch The Video On Spark 360

• Spark 360, November 2011. Rene San Miguel’s video features interviews with Dr. Sam Low and Dr. Pat Allen, who discuss the innovations in dental medicine presented by topical antioxidants.
Click Here To Watch The Video On Spark 360

• Spark 360, October 2011. Rene San Miguel’s video describes the background of PerioSciences products.
Click Here To Watch Rene San Miguel’s Video

Professional dental hygienists have also responded enthusiastically to the way AO ProVantage products add to their patients’ oral health, including patients with significant oral health challenges.

• Dentistry iQ, August 2011. “Oral antioxidants: A weapon in wound healing,” by Jamie White, RDH. Describes this dental professional’s recommendation to include AO ProVantage for patients recovering from oral surgery or other wounds.
Click Here To Read The Full Article On Dentistry iQ

• RDH Magazine, February 2012. “Antioxidants, free radicals, and oxidative stress” by Karen Davis, RDH, BSDH.
Click Here To Read The Full Article In RDH Magazine

• The Deziree Show, a blog for dental hygienists, includes a video of an interview with Karen Davis, RDH, from June 22, 2011. The discussion includes the oral/systemic link, oxidative stress, and the how AO ProVantage is especially helpful for the oral care of patients who smoke.
Click Here To Read The Full Article On The Deziree Show

• RDH Magazine, October 2011. “UOR is once again an amazing meeting,” by Kim Miller, RDH, BSDH. A review of the RDH Under One Roof conference in Chicago, where she was wowed by the PerioSciences product line.

For a complete view of publications that have featured PerioSciences products or articles related to the use of dental antioxidants, check out the website.

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Green Tea for Earth Day

Green Tea For Earth DayEarth Day is April 22 this year. The first Earth Day was in 1970, and it is sometimes credited as the beginning of the modern environmental movement. Earth Day is a great time to think about clean air, clean water, and the protection of our environment and its bounty.

We might also take Earth Day as a reason to think about Green Tea (it grows on plants from the earth, you see). Green tea comes from the Camellia sinensis plant, as do black tea and oolong tea. Green tea, however, is the least processed of the three major kinds of tea, and it has become increasingly popular because of its abundant beneficial components.

If you do an Internet search, or just pick up a health-oriented magazine, you’ll find an avalanche of information touting the benefits of green tea. It is supposed to help with cancer, cholesterol, heart disease, infection, obesity, high blood sugar, rheumatoid arthritis, and more. It’s also credited with improving mental function, mood, and many other conditions.

Antimicrobial, antibacterial, antioxidant

Some of the credit is given to green tea’s antimicrobial properties. That is, some of its polyphenols have been shown to attack bacteria and other microorganisms. Credit is also given to green tea’s anti-inflammatory and antioxidant properties. The University of Maryland Medical Center writes on its health website, “Green tea … reportedly contains the highest concentration of powerful antioxidants called polyphenols. Antioxidants are substances that fight free radicals — damaging compounds in the body that change cells, damage DNA, and even cause cell death. Many scientists believe that free radicals contribute to the aging process as well as the development of a number of health problems, including cancer and heart disease. Antioxidants such as polyphenols in green tea can neutralize free radicals and may reduce or even help prevent some of the damage they cause.”

Oral health benefits

Scientists have researched the effects of green tea components on oral health as well. The Department of Preventive Dentistry at Okayama University of Graduate School of Medicine in Japan experimented with green tea catechins on rats to see if there was any effect on periodontal inflammation. The study concluded, “Adding green tea catechins to a dentifrice may contribute to prevention of periodontal inflammation by decreasing gingival oxidative stress and expression of pro-inflammatory cytokines.” In other words, green tea extracts have antioxidant properties that are beneficial for oral tissues.

Good for bad breath

It turns out that green tea components have also been shown to counteract the volatile sulfur compounds (VSCs) that cause bad breath. Scientists at the Department of Oral Biological and Medical Sciences at the University of British Columbia in Vancouver, Canada conducted studies on the antimicrobial and deodorant effects of green tea polyphenols. They concluded “…that green tea was very effective in reducing oral malodor temporarily because of its disinfectant and deodorant activities, whereas other foods were not effective.”

At PerioSciences, we included green tea catechins in our AO ProRinse. Not only does this antioxidant-based breath rinse cool and soothe oral tissues, it contains those green tea ingredients that have been shown to counteract volatile sulfur compounds—further assuring clean, fresh breath.
Celebrate this Earth Day with a cup of green tea. And as you breathe in clean fresh air—thanks to Earth Day environmentalism—you can also breathe out clean, fresh breath: thanks to PerioSciences AO ProRinse with green tea catechins.

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